ATVB Journal Supplement

Faculty: Garrett A. Fitzgerald, MD (Chair), Lawrence Brass, MD, PhD, Jane E. Freedman, MD, Hyung-Hwan Kim, PhD, James K. Liao, MD, Andreas E. May, MD, Alan D. Michelson, MD, Carlo Patrono, MD, Guy A. Zimmerman, MD

Credit: Up to 5.5 AMA PRA Category 1 ^TM
Fee: No charge

Original Release Date: 02/25/2008
Expiration Date: 03/31/2009
Last Review Date: 02/25/2008

Sponsorship: This activity is co-sponsored by the University of Pennsylvania School of Medicine and education | outcomes | science.

Format: PDF & HTML

Program Description

These proceedings are derived from a satellite meeting held in conjunction with the annual scientific meeting of the Council on Arteriosclerosis, Thrombosis and Vascular Biology of the American Heart Association, held in Chicago in April of 2007. It is titled “Translational Therapeutics at the Platelet-Vascular Interface,” and was designed to highlight how information on basic mechanisms derived from cells and model systems might be integrated with current understanding of drug action in humans.

This self-study CME activity consists of seven manuscripts, an introduction, and summary remarks, and is certified for CME credit in its entirety. Undoubtedly, individual learners may be interested in reviewing the manuscripts individually.

Commercial Support

This activity is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.

Intended Audience

This educational activity is designed for scientists/clinicians in the areas of cardiovascular research, molecular/cellular biology, epidemiology, clinical cardiology, hematology, and neurology.

Educational Objectives:

After participating in this activity, participants should be able to:

• Review current understanding of platelet and vascular physiology and its implications for clinical practice
• Recognize the rationale for use of various antiplatelet agents in patients with atherothrombotic disease
• Apply evidence for the clinical effects of various antiplatelet agents from randomized controlled trials in appropriate patients with atherothrombotic disease
• Discuss best available evidence to encourage use of appropriate antiplatelet agents for prevention and treatment of atherothrombotic disease
• Understand novel directions in the development of new antiplatelet agents

Registration Instructions

You must sign-up for an account. If you do not have an account please sign-up now (click on member sign-up at the top of the page). If you have an account make sure you are logged in to the CME Portal with your e-mail address and password (click on log in). You must then register for the activity by using the link in the "Course Materials" box on the right. Once you are registered for the activity, you will be able to click on the BEGIN THE ACTIVITY link in the "Course Materials" box. Review the introduction, all 7 articles, and the summary. At the conclusion of the activity, click on "Post-Test, Evaluation, CME Credit" and a post-test will be available to you. Upon receiving a passing score of 70% or higher and completing an evaluation of the activity, you will be able to view and print a CME certificate verifying your credit for this activity.

Computer Requirements

Internet Explorer 5.0 or above, Mozilla Firefox 1.0.7 or above
PDFs can be viewed with Adobe Acrobat Reader. Click here to download.

Faculty

Activity Chair
Garret A. FitzGerald, MD
Professor of Medicine
Elmer Bobst Professor of Pharmacology
Chair, Department of Pharmacology
Director, Institute for Translational Medicine and Therapeutics
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania

Primary Faculty
Lawrence Brass, MD, PhD
Professor of Medicine and Pharmacology
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania

Jane E. Freedman, MD
Associate Professor of Medicine and Pharmacology
Boston University School of Medicine
Boston, Massachusetts

Hyung-Hwan Kim, PhD
Instructor in Medicine
Harvard Medical School
Associate Physiologist
Brigham and Women’s Hospital
Boston, Massachusetts

James K. Liao, MD
Director, Vascular Medicine Research
Brigham & Women's Hospital
Associate Professor of Medicine
Harvard Medical School
Cambridge, Massachusetts

Andreas E. May, MD
Associate Professor of Medicine and Cardiology
University of Tübingen
Tübingen, Germany

Alan D. Michelson, MD
Director, Center for Platelet Function Studies
Professor of Pediatrics, Medicine, and Pathology
University of Massachusetts Medical School
Worcester, Massachusetts

Carlo Patrono, MD
Professor of Pharmacology
Catholic University School of Medicine
Rome, Italy

Guy A. Zimmerman, MD
Director, Program in Human Molecular Biology and Genetics
Professor of Internal Medicine
University of Utah School of Medicine
Salt Lake City, Utah

Accreditation:

The University of Pennsylvania School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation of credit

The University of Pennsylvania School of Medicine designates this educational activity for a maximum of 5.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosures

It is policy at the University of Pennsylvania School of Medicine for individuals who are in a position to control the content of an educational activity to disclose to the learners all relevant financial relationships that they have with any commercial interest that provides products or services that may be relevant to the content of this continuing medical education activity.

The staff in the Office of CME at the University of Pennsylvania, the peer reviewer, and the staff at education | outcomes | science, our educational partner, have reported no relevant financial relationships with any commercial interests related to the content of this educational activity.

The following faculty have reported no relevant financial relationships with commercial interests related to the content of this educational activity:
Lawrence Brass, MD, PhD
Meinrad Gawaz, MD
Hyung-Hwan Kim, PhD
Andreas E. May, MD
Peter Seizer, MD
Tim Stalker, PhD
Andrew S. Weyrich, PhD
Li Zhu, MD, PhD

The following faculty have reported the listed relevant financial relationships with commercial interests related to the content of this educational activity:

Jane E. Freedman, MD, has received grant/research support from Momenta Pharmaceuticals, Inc.

James K. Liao, MD, has been a consultant for Asahi Kasei Corporation, AstraZeneca, Boehringer Ingelheim, Merck & Co., Inc., and Pfizer Inc; has received grant/research support from AstraZeneca and Pfizer Inc; has been on the speakers’ bureau for AstraZeneca, Boehringer Ingelheim, and Merck & Co., Inc.; and is a stockholder for eNOS Pharmaceuticals.

Alan D. Michelson, MD, has been a consultant for McNeil Consumer Healthcare; has received grant/research support from Accumetrics, Eli Lilly/Daiichi Sankyo, and McNeil Consumer Healthcare; and has been on the speakers’ bureau for sanofi-aventis/Bristol-Myers Squibb.

Carlo Patrono, MD, has been a consultant for Bayer, NicOx, sanofi-aventis, and Servier; and he has been on the speakers’ bureau for AstraZeneca and Bayer.

Biana Rocca, MD, has been on the speakers’ bureau for Bayer, Bristol-Myers Squibb, and Nycomed.

Guy A. Zimmerman, MD, has been on the speakers’ bureau for Novo Nordisk.

Discussion of investigational and/or off-label use of commercial products and devices

The University of Pennsylvania School of Medicine requires all faculty to disclose any discussion of an investigational and/or off-label use of a pharmaceutical product or device within their presentations. Participants should note that the use of products outside FDA-approved labeling should be considered experimental and are advised to consult current prescribing information for approved indications.

Faculty reported the following specific mentions of off-label and/or investigational use of products.
Product - dipyridamole
Investigational and/or Off-Label Use - anti-inflammatory, anti-ischemic, antioxidant